Amongst individuals on the lookout for pure well being cures, barley grass merchandise have been gaining recognition due to its big selection of vitamins. Often consumed as a juice powder stirred into water or a smoothie or as dried entire leaf powder, the barley leaves are wealthy in nutritional vitamins, minerals, and antioxidants—like flavonoids (for instance, saponarin, lutonarin, Bz-TMF, and some others that we now have highlighted in our blogs).
Often, individuals consider barley grass merchandise for advantages like detoxing, rising power ranges, and serving to with irritation . However through the years, some analysis in lab mice suggests additionally they play a task in serving to alleviate signs of despair which are brought on by stress.
Despair is a really complicated situation. Though it impacts tens of millions of individuals worldwide it’s nonetheless very troublesome to deal with and overcome. It is typically linked to emphasize, oxidative injury, and imbalances in mind chemical substances like serotonin and different neurotrophic elements. (Although the speculation of serotonin and despair is fallacious and was principally made as much as promote medication.) And talking of medicine, there are some huge money-makers on the market for treating despair, however one of many unwanted effects of those medication is despair and suicidal tendencies. So, numerous individuals like you might be in search of out pure options. May barley grass assist?
On this weblog, we’ll take a look at three intriguing research with lab mice that present some antidepressant-like results when the mice are given barley grass powder. Now these are simply animal experiments, so they don’t seem to be straight relevant to people, however they do offer you a bit perception as to how barley grass juice powder may assist. So let’s try these research.
Examine 1: Barley and Wheat Grass Extracts Assist Mice Deal with Stress-Induced Despair
Barley grass powder merchandise have change into widespread in Nepal. This prompted a research in 2022 that was revealed within the Journal of Ayurveda and Integrative Medication. On this research the researchers explored the consequences of aqueous extracts from barley and wheat grass on Swiss albino mice subjected to stress-induced despair. The researchers hypothesized that the antioxidants within the extract would have antidepressant properties.
- Strategies: Mice had been divided into teams and uncovered to emphasize. They obtained both the extracts (400 mg/kg), an ordinary antidepressant (imipramine, 100 mg/kg), or a management. Behavioral checks included the compelled swim check (FST), tail suspension check (TST), and elevated plus maze (EPM) to evaluate immobility (a proxy for despair) and anxiousness.
- Key Findings: The extracts contained bioactive compounds like alkaloids, flavonoids, phenols, and tannins, with excessive whole phenolic and flavonoid content material contributing to sturdy antioxidant exercise. In behavioral checks, handled mice confirmed considerably diminished immobility time in FST and TST (p < 0.05 to p < 0.01) and spent extra time within the open arms of the EPM (p < 0.01), indicating diminished anxiousness and depression-like behaviors in comparison with the burdened management mice.
- Implications: This research means that barley grass and wheat grass extracts have antidepressant exercise in them. This may be as a result of antioxidant polyphenols and flavonoids that naturally happen in these vegetation.
Examine 2: Barley Leaf Extract helps Mice Overcome Stress within the Pressured Swimming Take a look at
A Japanese analysis group at Chiba College in Japan revealed their preliminary findings in 2012. This research in Pharmacognosy Analysis centered particularly on younger inexperienced barley leaf powder and its antidepressant potential in mice utilizing the compelled swimming check, which is a typical mannequin for screening antidepressants.
- Strategies: Mice had been orally given barley leaf extract (400 or 1000 mg/kg) or imipramine (100 mg/kg) (a tricyclic antidepressant) one hour earlier than swimming classes over three days. Immobility length was measured, and mind mRNA ranges of nerve progress issue (NGF), brain-derived neurotrophic issue (BDNF), and glucocorticoid receptor (GR) had been analyzed within the hippocampus and cortex.
- Key Findings: Each doses of barley leaf considerably diminished immobility time (indicating an antidepressant-like impact), just like imipramine. Stress elevated NGF mRNA within the hippocampus by 31%, however barley leaf moderated this in a dose-dependent manner. BDNF and GR ranges weren’t considerably altered, and serum corticosterone (a stress hormone) remained unchanged by the extract.
- Implications: The researchers suggest that barley leaf’s results may contain modulating NGF within the mind, doubtlessly providing safety to nerve cells towards stress with out straight impacting the stress hormone axis. Just like the earlier research, this one additionally factors to secondary metabolite molecules (equivalent to polyphenols and flavonoids) as antioxidants in barley grass as main elements in altering the mice’s conduct.
Examine 3: Protecting Results of Barley Leaf Extract on Stress and Mind Well being
A follow-up research from the identical analysis group in Japan was revealed in 2015 in Pharmacognosy Journal. This analysis examined younger inexperienced barley leaf’s means to guard towards restraint stress in feminine mice. They measured voluntary wheel working conduct (burdened mice do not run as a lot) and measurement of mRNA ranges of BDNF within the hippocampus. Mind-derived neurotrophic issue (BDNF) is like progress issue for nerve cells. It’s essential for neuron survival and infrequently diminished in despair.
- Strategies: Mice underwent restraint stress for 3 hours every day over 5 days, with barley leaf (400 or 1000 mg/kg) or a constructive management (clotiazepam, 10 mg/kg) given orally beforehand. Wheel-running exercise (a measure of motivation and anti-stress adaptation) was tracked, together with serum corticosterone, and BDNF mRNA (together with variants like exon IV).
- Key Findings: Stress decreased wheel-running and hippocampal BDNF mRNA (whole, exon I, and exon IV) as anticipated. Barley leaf (particularly 400 mg/kg) prevented the drop in exercise and considerably boosted BDNF exon IV mRNA (p < 0.05). It did not have an effect on corticosterone ranges, suggesting that the consequences had been impartial of the primary stress hormone pathway (the struggle or flight pathway talked about a lot).
- Implications: By preserving BDNF, barley grass might assist preserve hippocampal well being beneath stress, doubtlessly preserving depression-like states at bay. The research highlights its position in selling resilience with out stimulating the nervous system, as there was no hyperactivity or additional wheel-running conduct in non-stressed mice given the barley leaf extract,
What Does This Imply for People?
Taken collectively, these mice research counsel three ways in which Barley Grass extracts and juices may have antidepressant-like properties:
1. Discount of oxidative stress by way of antioxidants.
2. Normalization of mind elements like nerve progress issue (NGF) and brain-derived neurotrophic issue, BDNF, which assist nerve well being.
3. Enhancement of conduct outcomes when uncovered to emphasize with out toxicity or overstimulation.
However we nonetheless should be cautious about extrapolating these outcomes. These are simply mice and the ends in mice do not actually translate to people very properly. These outcomes are preliminary. Despair in individuals is way more sophisticated than stress-induced despair in mice. It’s important to take many elements under consideration, together with genetics, way of life elements, and the atmosphere—issues that are not actually explored in these easy research.
Nevertheless, we do know that barley grass is mostly protected and customarily useful to individuals, whether or not you are in Nepal, Japan, or right here within the USA. So should you’re coping with despair, you could need to consider using one thing like BarleyMax simply to enrich no matter else you are doing. It is not an alternative to different issues, nevertheless it could possibly be useful to include it into your weight loss plan. It simply may make it easier to overcome stress and really feel higher.