I’ve been working within the males’s well being discipline since 1969. My work expanded tremendously in 1997 following the publication of my fourth guide, Male Menopause, which quickly grew to become a global best-seller translated into seventeen international languages. Within the guide I outlined the male “change of life” this fashion:
“Male menopause (additionally referred to as andropause or manopause) begins with hormonal, physiological, and chemical adjustments that happen in all males usually between the ages of forty and fifty-five, although it could happen as early as thirty-five or as late as sixty-five. These adjustments have an effect on all elements of a person’s life. Male menopause is, thus, a bodily situation with psychological, interpersonal, social, and non secular dimensions.”
I went on to say,
“The aim of male menopause is to sign the top of the primary a part of a person’s life and put together him for the second half. Male menopause isn’t the start of the top, as many worry, however the finish of the start. It’s the passage to essentially the most passionate, highly effective, productive, and purposeful time of a person’s life.”
I listed the next signs I had seen through the years with shoppers I handled. Probably the most widespread bodily signs embody:
- Much less endurance for bodily exercise
- Taking longer to recuperate from accidents and sickness
- Weight achieve
- Lack of pores and skin tone
Frequent psychological signs embody:
- Irritability
- Nervousness
- Melancholy
- Lack of goal and route in life
Frequent sexual signs embody:
- Lack of erections
- Low libido and curiosity in intercourse
- Elevated anxiousness and worry about sexual adjustments
- Elevated fantasies about having intercourse outdoors of major relationship
I mentioned the influence of hormonal adjustments for males going via this life passage.
“Lowered ranges of hormones at midlife are central to the adjustments related to male menopause. Though hormones are likely to lower with age, every man is exclusive and particular person ranges fluctuate extensively. In a single examine, for example, the typical degree of testosterone for males of their fifties was 600 ng/ mL. Nevertheless, particular person ranges ranged from 200 ng/ mLl to 1,000 ng/ mL.”
I additionally detailed the early experiences with testosterone alternative therapies (TRT) and a number of the considerations about its use.
“Whereas clinicians within the U.S. debated the dangers and advantages of TRT, British physicians had been already starting to make use of hormones to deal with males who confirmed signs of testosterone deficiency.”
Over time, there continues to be controversy about using TRT in treating males. Nonetheless, testosterone continues to be prescribed extensively for hundreds of thousands of males. I not too long ago wrote a couple of new firm, GameDay Males’s Well being, that has been increasing quickly with new clinics all through the nation. Says their founder, Evan Miller, PhD,
“By focusing all of our vitality on delivering premium testosterone alternative remedy, eradicating the stigma round erectile dysfunction providers and extra, we guarantee our shoppers’ expertise is stress-free, quick, and most significantly, delivers outcomes.”
Acesis BioMed: Revolutionizing Therapy of Low T and Different Well being Issues
I not too long ago realized a couple of new firm, Acesis Biomed, that’s taking a unique method to treating low testosterone in males. Acesis Biomed was based by Dr. Vassilios Papadopoulos and Dr. Costas N. Karatzas.
Dr. Papadopoulos is Dean of the College of Southern California Alfred Mann Faculty of Pharmacy & Pharmaceutical Sciences. He holds the John Stauffer Decanal Chair in Pharmaceutical Sciences and is a professor of Pharmacology and Pharmaceutical Sciences and Medication at USC. Earlier than becoming a member of USC, Dr Papadopoulos served as Govt Director and Chief Scientific Officer of the Analysis Institute of McGill College Well being Centre in Montreal, Canada.
Dr. Karatzas is Acesis’ CEO and has over 35 years of expertise in Life Sciences within the public, personal and tutorial sectors. He attended McGill College, the place he earned his Ph.D., in Molecular Biology. He has over fifty peer-reviewed publications and is an inventor with 18 patents. From 2009 to 2021 he was the Director of Enterprise Improvement and Contracts Workplace on the Analysis Institute of the McGill College Well being Centre, Montreal, Canada.
I not too long ago had a chance to speak with Drs. Papadopoulos and Karatzas about their firm and their new method for serving to males with low T. They informed me,
“Tens of millions of males undergo from low testosterone (T), resulting in decreased high quality of life. Acesis Biomed is pioneering a first-in-class, patented, oral therapy that restores the physique’s pure T manufacturing — with out artificial hormones.”
From my expertise working with mid-life males and their households for greater than fifty years, I imagine this can be a monumental breakthrough in what will likely be provided to males. Up till now, males who had been experiencing signs of low testosterone had been restricted to taking Testosterone Substitute Remedy (TRT). Now, for the primary time, Acesis Biomed, is providing a therapy method that helps males restore their testosterone ranges via a doubtlessly safer and extra pure method by inducing the testes to supply testosterone.
“Our imaginative and prescient is to unlock the physique’s capacity to revive testosterone, slightly than utilizing exterior steroids, setting a brand new method for males’s wellbeing,” they informed me.
They proceed by stating:
“What if a capsule might assist hundreds of thousands of males really feel like themselves once more — with out needles, patches, gels or artificial hormones? At Acesis, we’re on a mission to rework the way in which low-T or deficiency is handled.“
Dr. Karatzas said that,
“Our distinctive answer is rooted within the science, developed by Dr. Papadopoulos. His analysis has led to a greater understanding of the pathways resulting in steroid hormone synthesis, the pharmacology of steroid formation within the periphery and mind, and the identification of recent molecules concentrating on key parts in illnesses the place steroids play a figuring out position.”
They informed me they need to make certain that when this new medicine is out there, it’s secure and has undergone the required medical trials and regulatory scrutiny.
“Our present objective is to finish our preclinical program and transition to First-in-Man medical trial in males with low testosterone, often known as male hypogonadism.”
As a pacesetter within the discipline of Gender-Particular Medication and Males’s Well being I’m excited to proceed studying extra in regards to the ground-breaking work that Drs. Papadopoulos and Karatzas are doing.
The sector of Gender-Particular Medication is comparatively new. My colleague, Marianne J. Legato, MD based the Basis for Gender-Particular Medication in 1999. In her guide, Eve’s Rib: The New Science of Gender-Particular Medication and How It Can Save Your Life, she says,
“Till now, we’ve acted as if women and men are basically equivalent apart from the variations of their reproductive operate. Actually, data we’ve been gathering over the previous ten years tells us that that is something however true, and in every single place we glance, the 2 sexes are startingly and unexpectedly totally different not solely of their regular operate however in the way in which they expertise sickness.”
Dr. Legato has informed me on quite a few events that there’s a nice want for brand new approaches to serving to males. In her guide, Why Males Die First: The best way to Lengthen Your Lifespan, she says,
“Regardless of the numerous alternatives and benefits most societies afford males, they continue to be shockingly susceptible on many ranges. Researchers have largely ignored the phenomenon, with tragic penalties. Merely put, we by no means turned a gender-specific lens on males. We’ve got not thought sufficient — if in any respect — about why they’re uniquely vulnerable to incapacity and untimely loss of life.”
It’s time that males’s well being received the popularity it deserves. I’ll maintain my readers posted on these improvements and sit up for listening to extra from Dr. Vassilios Papadopoulos and Dr. Costas N. Karatzas sooner or later. You’ll be able to be taught extra about Acesis BioMed and their work to rework males’s well being by visiting their web site right here. If you need to subscribe to my free weekly publication and skim articles about improvements in discipline, you may go to me at MenAlive.com and subscribe to the publication right here.