Tahoe Therapeutics – a biotech start-up primarily based in San Francisco, California – is creating the most important ever atlas of cell-chemical interactions to tell drug discovery. Combining automated pipetting methods from INTEGRA Biosciences, Parse Biosciences’ Evercode™ single-cell RNA sequencing (scRNA-seq) merchandise, and its personal proprietary AI algorithms, the corporate already has a number of drug discovery packages working in parallel throughout a number of most cancers sorts, and is increasing into different therapeutic areas.
Workflow automation is important for the Tahoe Therapeutics workforce’s goal of producing a number of the largest scRNA-seq datasets on the earth. The corporate invested in an ASSIST PLUS pipetting robotic and VIAFLO handheld digital pipette to automate its analysis workflows. INTEGRA’s partnership with Parse Biosciences means these instruments work seamlessly with the Evercode merchandise to supply a validated, turnkey resolution overlaying each stage of scRNA-seq pattern preparation. These instruments allow the corporate to scale up its operations whereas bettering reliability and lowering hands-on time by as much as 75 p.c.
The corporate goals to make use of the pace and accuracy of those automated methods to generate a dataset fifty occasions bigger than its already record-breaking Tahoe 100 million single-cell atlas.
We rapidly realized that, as we have been producing an increasing number of knowledge and pushing the boundaries of the sector, we have been lacking robotic and excessive throughput options. Automation with the ASSIST PLUS has elevated our throughput for single-cell preparation greater than 5-fold. Crucial factor is that it is extremely correct: you are not counting on the inherent variability of guide processing. The mix of INTEGRA’s devices and Parse Biosciences’ kits permits us to leapfrog many biopharmaceutical corporations and generate bigger datasets utilizing much less instrumentation, reagents and capital.”
Johnny Yu, Co-founder and Chief Scientific Officer, Tahoe Therapeutics